The SPQ is regarded as a sensitive instrument to measure subclinical schizophrenia-like traits or symptoms Social behavior and autism traits in a sex chromosomal disorder: Klinefelter 47XXY syndrome. It has been suggested that X-linked imprinting may serve as a mechanism for the evolution of sexual dimorphism in humans, given that gene dosages of X-linked imprinted genes are expected to differ between the sexes 26 , Men with KS often present with language based learning problems, cognitive dysfunction and social difficulties 1 , 14 , Br J Psychiatry. These numbers were too small for further comparisons, but the hetero- vs.
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Behav Brain Sci. The significantly higher scores on schizotypal traits were consistently associated with maternal origin. Determination of parent-of-origin of the extra X chromsome in this sample showed that in 19 subjects the extra X chromosome originated from the mother maternal group and in 14 subjects from the father paternal group. The first difference contrast KS vs.
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Good Girls Gone Bad. Figure 2 gives an overview of the ADI-R label scores. To our knowledge, no studies have found autistic trait differences between autistic males and females.
The Prader-Willi PWS and Angelman AS syndromes are clinically distinct developmental disorders with frequent psychotic and autistic symptoms respectively which are caused by genetic defects in the imprinted domain at chromosome 15qq13, resulting in the loss of paternal PWS or maternal AS gene function 23 , Thanks for using Apache and CentOS! Figure 3. The 1 st contrast controls vs. The ADI-R measures autistic behaviors that are called items. Parent-of-origin of the X chromosome was determined through analysis of the polymorphic CAG tandem repeat of the androgen receptor. Am J Psychiatry.